Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum
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Improved ganoderic acids production in Ganoderma lucidum by wood decaying components
Ganoderma lucidum is a legendary Traditional Chinese Medicine (TCM) over a few thousands of years and one kind of its major active components are Ganoderic acids (GAs). GAs are largely produced in the mushroom primordium and fruiting body but much less in mycelium stage. However, little is known on the underlying regulatory mechanism. As a saprophytic fungus, G. lucidum solely obtains nutrients...
متن کاملimpact of rifampin induction on the fermentation production of ganoderic acids by medicinal mushroom ganoderma lucidum
backgrounds and objectives : ganoderic acids are the most valuable secondary metabolites in ganoderma lucidum traditional medicinal mushrooms, which have shown antitumor properties in many studies. however, application of ganoderic acids is limited due to low yield production. recently, it was shown that static liquid culture could be a proven technology for producing ganoderic acids in ganoder...
متن کاملA Novel Approach to Enhancing Ganoderic Acid Production by Ganoderma lucidum Using Apoptosis Induction
Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia, and ganoderic acids (GAs) are its active ingredients. Regulation of GA biosynthesis and enhancing GA production are critical to using G. lucidum as a medicine. However, regulation of GA biosynthesis by various signaling remains poorly understood. This study investigated the role of apoptosis signaling on G...
متن کاملRole of oxygen supply in submerged fermentation of Ganoderma lucidum for production of Ganoderma polysaccharide and ganoderic acid
The effects of oxygen supply on the submerged fermentation of Ganoderma lucidum, a famous traditional Chinese medicinal mushroom, for simultaneous production of bioactive compounds—Ganoderma polysaccharide and ganoderic acid (GA) were studied. An initial volumetric oxygen transfer coefficient (KLa) value within the range of 16.4–96.0 h−1 had a significant effect on the cell growth, cellular mor...
متن کاملPerformance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum.
Investigations on Ganoderma lucidum fermentation suggested that the responses of the cell growth and metabolites biosynthesis to pH and dissolved oxygen tension (DOT) were different. The ganoderic acid (GA) production of 321.6 mg/L was obtained in the pH-shift culture by combining a 4-day culture at pH 3.0 with the following 6-day culture at pH 4.5, which was higher by 45% and 300% compared wit...
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ژورنال
عنوان ژورنال: Microbial Cell Factories
سال: 2019
ISSN: 1475-2859
DOI: 10.1186/s12934-019-1164-3